Medical Director, Clinical Safety
Posted on November 23, 2025 (about 1 hour ago)
Company introduction:
Compass Pathways plc (Nasdaq: CMPS) is a biotechnology company dedicated to accelerating patient access to evidence-based innovation in mental health. The company is headquartered in London, UK, with offices in New York City, US. They focus on developing novel treatments to improve the lives of people with mental health conditions unhelped by current treatments.
They are pioneering a new paradigm for treating mental health conditions using their investigational COMP360 synthetic psilocybin treatment, potentially a first-in-class treatment. COMP360 has Breakthrough Therapy designation from the US FDA and Innovative Licensing and Access Pathway (ILAP) designation in the UK for treatment-resistant depression (TRD).
Currently in phase 3 for TRD, they have completed phase 2 studies for PTSD and anorexia nervosa and plan further late-stage PTSD studies. They envision a world where mental health means the ability to thrive, not just absence of illness.
Job Overview:
The Medical Director, Clinical Safety is responsible for medical oversight of Compass-sponsored clinical studies, serving as a subject matter expert and providing expertise in strategic development planning for pipeline compounds.
Location: Remote in the United Kingdom or hybrid in Soho, London office.
Reports to: Vice President of Clinical Safety and Pharmacovigilance.
Roles and Responsibilities:
- Oversee CRO medical monitoring in phase 2 and 3 studies
- Serve as primary medical monitor for phase I studies
- Support DSMB meetings and data review as Responsible Study Physician
- Provide medical and psychiatry expertise for clinical study design, data interpretation, literature review
- Author and review clinical study documents and regulatory submissions
- Contribute to clinical trial data presentation internally and externally
- Offer strategic expertise in development planning for pipeline compounds
- Participate in scientific assessment and due diligence for business development opportunities
- Lead workstreams, supervise junior colleagues, interact with development teams and senior leadership
- Ensure compliance with ethical, regulatory, and quality standards for participant safety and data integrity
- Collaborate with senior leadership on clinical development, asset prioritization, therapeutic direction
- Represent the company externally to clinical sites, opinion leaders, patient advocacy groups, scientific organizations
- Work with clinical operations to meet time, cost, and quality project goals
- Ensure research programs comply with industry standards and internal SOPs
- Build relationships with global investigators and thought leaders, oversee advisory boards, investigator meetings, conferences
Candidate Profile:
- MD, MBBS, or equivalent, licensed to practice medicine in the US or UK
- Fully qualified psychiatrist strongly preferred
- Extensive CNS clinical research experience in pharmaceutical drug development, CRO medical monitoring, or industry-sponsored studies
- Strong knowledge of scientific principles, concepts, communications
- Expertise in clinical research and statistical methods
- Good understanding of pharmaceutical drug development and regulatory guidances
- Demonstrated teamwork, leadership, communication skills
Benefits & Compensation:
For overview of benefits and compensation, visit "Working at Compass" on company website.
Equal opportunities:
Committed to diversity, inclusion, and equality as per relevant laws. Reasonable accommodations during interview available. Non-discrimination based on protected characteristics in UK and US employment.
Sponsorship:
Cannot sponsor employment visas; applicants must have employment rights in the applying country.
Data Privacy:
All data confidential and processed according to legal and privacy requirements. Refer to recruitment Privacy Notice on website.
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Please submit your application via the company's application page linked from the original job posting website. Fill in all required fields and attach necessary documents such as Resume/CV and Cover Letter.